Bromodomain protein inhibition protects β-cells from cytokine-induced death and dysfunction via antagonism of NF-κB pathway

Abstract excerpt

<h4>ABSTRACT</h4> Cytokine induced β-cell apoptosis is the major pathogenic mechanism in type 1 diabetes (T1D). Despite significant advances in understanding underlying mechanisms, few drugs have been translated to protect β-cells in T1D. Epigenetic modulators such as bromodomain-containing BET (Bromo- and Extra-Terminal) proteins are important regulators of immune responses. Pre-clinical studies have demonstrate...

Topics

Open a Topic to create a Post that cites this publication.

• CD4-Positive T-Lymphocytes
• Diabetes Mellitus, Type 1
• Heterocyclic Compounds, 4 or More Rings
• Insulin-Secreting Cells
• Mice, Inbred NOD
• Monocytes
• NF-kappa B
• Regeneration

Identifiers and source

Literature Corpus work

57de61ef-3c80-57db-856f-952bbf84b72f

DOI

10.1101/2020.11.05.363408