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Inhibitors of bromodomain and extra‐terminal proteins for treating multiple human diseases

14 Sept 2020

Abstract excerpt

Clinical development of bromodomain and extra-terminal (BET) protein inhibitors differs from the traditional course of drug development. These drugs are simultaneously being evaluated for treating a wide spectrum of human diseases due to their novel mechanism of action. BET proteins are epigenetic "readers," which play a primary role in transcription. Here, we briefly describe the BET family of proteins, of which...

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PMID: 32926459
DOI: 10.1002/med.21730

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