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Article

Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells.

eLife - 19 Nov 2014

Fu Wenxian, Farache Julia, Clardy Susan M, Hattori Kimie, Mander Palwinder, Lee Kevin, Rioja Inmaculada, Weissleder Ralph, Prinjha Rab K, Benoist Christophe, Mathis Diane

Abstract excerpt

Epigenetic modifiers are an emerging class of anti-tumor drugs, potent in multiple cancer contexts. Their effect on spontaneously developing autoimmune diseases has been little explored. We report that a short treatment with I-BET151, a small-molecule inhibitor of a family of bromodomain-containi...

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Share to CD4-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25407682
DOI: 10.7554/eLife.04631
PMCID: PMC4270084

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25407682-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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