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Article

Structural Integrity of the A147T Polymorph of Mammalian TSPO.

Chembiochem : a European journal of chemical biology - 6 Jul 2015

Jaremko Mariusz, Jaremko Łukasz, Giller Karin, Becker Stefan, Zweckstetter Markus

Abstract excerpt

Ligands of the transmembrane protein TSPO are used for imaging of brain inflammation, but a common polymorphism in TSPO complicates their application to humans. Here we determined the three-dimensional structure and side-chain dynamics of the A147T polymorph of mammalian TSPO in complex with the...

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Identifiers

PMID: 25974690
DOI: 10.1002/cbic.201500217
PMCID: PMC5653209

Genes

TSPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25974690-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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