Development and evaluation of [11C]DPA-813 and [18F]DPA-814: novel TSPO PET tracers insensitive to human single nucleotide polymorphism rs6971.

doi:10.1007/s00259-025-07109-1

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Article

Development and evaluation of [11C]DPA-813 and [18F]DPA-814: novel TSPO PET tracers insensitive to human single nucleotide polymorphism rs6971.

European journal of nuclear medicine and molecular imaging - 1 Jun 2025

Beaino Wissam, Jm Kooijman Esther, Werry Eryn L, Vellinga Rens J, Van den Hoek Johan, Sohler Greta, Cumbers Grace A, Genetzakis Elijah, Harvey-Latham Edward D, Schuit Robert C, Kassiou Michael, Windhorst Albert D, Danon Jonathan J

Abstract excerpt

PURPOSE: The translocator protein 18 kDa (TSPO) is a widely used marker for imaging neuroinflammation via Positron Emission Tomography (PET). However, the vast majority of reported TSPO PET tracers display low binding affinity to a common isoform of human TSPO (rs6971; A147T), making them unsuitable for universal use in the general population. In this study, we have developed and preclinically validated two novel...

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Identifiers

PMID: 39907797
DOI: 10.1007/s00259-025-07109-1
PMCID: PMC12119672

Genes

TSPO

Variants

rs6971

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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