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Article

Effects of genetic variants in the TSPO gene on protein structure and stability.

PloS one - 1 Jan 2018

Milenkovic Vladimir M, Bader Stefanie, Sudria-Lopez Daniel, Siebert Ramona, Brandl Caroline, Nothdurfter Caroline, Weber Bernhard H F, Rupprecht Rainer, Wetzel Christian H

Abstract excerpt

The 18 kDa translocator protein (TSPO) is an evolutionary conserved cholesterol binding protein localized in the outer mitochondrial membrane. Expression of TSPO is upregulated in activated microglia in various neuroinflammatory, neurodegenerative, and neoplastic disorders. Therefore, TSPO radioligands are used as biomarkers in positron emission tomography (PET) studies. In particular, a common A147T polymorphism...

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Identifiers

PMID: 29641545
DOI: 10.1371/journal.pone.0195627
PMCID: PMC5895031

Genes

TSPO

Provenance

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Effects of genetic variants in the TSPO gene on protein structure and stability.PMID 29641545Read ↗

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Tricyclic heterocycles display diverse sensitivity to the A147T TSPO polymorphism.Semantic proximity Read ↗

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The Translocator Protein (TSPO) Genetic Polymorphism A147T is Associated with Worse Survival in Male Glioblastoma PatientsSemantic proximity Read ↗

An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28.Semantic proximity Read ↗

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