Bipolar Disorder is associated with the rs6971 polymorphism in the gene encoding 18 kDa Translocator Protein (TSPO).

doi:10.1016/j.psyneuen.2013.07.007

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Article

Bipolar Disorder is associated with the rs6971 polymorphism in the gene encoding 18 kDa Translocator Protein (TSPO).

Psychoneuroendocrinology - 1 Nov 2013

Colasanti Alessandro, Owen David R, Grozeva Detelina, Rabiner Eugenii A, Matthews Paul M, Craddock Nick, Young Allan H

Abstract excerpt

TSPO mediated transport of cholesterol into the mitochondrion is a necessary step in steroid synthesis. The rs6971 polymorphism in the TSPO gene causes an amino acid substitution (Ala147Thr) within the transmembrane domain where the cholesterol-binding pocket is located, and has been shown to affect the steroidogenic pathway. We report a nominal association between this TSPO polymorphism and the diagnosis of...

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PMID: 23942012
DOI: 10.1016/j.psyneuen.2013.07.007
PMCID: PMC3820042

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TSPO

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Bipolar Disorder is associated with the rs6971 polymorphism in the gene encoding 18 kDa Translocator Protein (TSPO).PMID 23942012Read ↗

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