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Article

Protein structure. Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism.

Science (New York, N.Y.) - 30 Jan 2015

Li Fei, Liu Jian, Zheng Yi, Garavito R Michael, Ferguson-Miller Shelagh

Abstract excerpt

The 18-kilodalton translocator protein (TSPO), proposed to be a key player in cholesterol transport into mitochondria, is highly expressed in steroidogenic tissues, metastatic cancer, and inflammatory and neurological diseases such as Alzheimer's and Parkinson's. TSPO ligands, including benzodiazepine drugs, are implicated in regulating apoptosis and are extensively used in diagnostic imaging. We report crystal...

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Identifiers

PMID: 25635101
DOI: 10.1126/science.1260590
PMCID: PMC5125025

Genes

TSPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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