Article

Defective flow-migration coupling causes arteriovenous malformations in hereditary hemorrhagic telangiectasia

2021-05-06

Abstract excerpt

<h4>Background</h4> Activin receptor-like kinase 1 ( ACVRL1 , hereafter ALK1 ) is an endothelial transmembrane serine threonine kinase receptor for BMP family ligands that plays a critical role in cardiovascular development and pathology. Loss-of-function mutations in the ALK1 gene cause type 2 hereditary hemorrhagic telangiectasia (HHT), a devastating disorder that leads to arteriovenous malformations (AVMs)....

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Literature Corpus work: f695313d-4715-5b1f-a81e-009413572e5a
DOI: 10.1101/2021.05.06.442985

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