Article

A Microphysiological HHT-on-a-Chip Platform Recapitulates Patient Vascular Lesions

2024-03-12

Abstract excerpt

Hereditary Hemorrhagic Telangiectasia (HHT) is a rare congenital disease in which fragile vascular malformations focally develop in multiple organs. These can be small (telangiectasias) or large (arteriovenous malformations, AVMs) and may rupture leading to frequent, uncontrolled bleeding. There are few treatment options and no cure for HHT. Most HHT patients are heterozygous for loss-of-function mutations for End...

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Literature Corpus work: ad067064-6202-5e68-8a0f-224d3ebcb5b1
DOI: 10.1101/2024.03.11.584490

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