Article

Loss of endothelial ALK1 signaling induces the emergence of a KIT+ angiogenic endothelial cluster driving brain arteriovenous malformations

2025-06-07

Abstract excerpt

<h4>Background</h4> Hereditary Hemorrhagic Telangiectasia type 2 (HHT2) is a genetic disorder caused by mutations in the ALK1 ( ACVRL1 ) gene, encoding a receptor for Bone Morphogenetic Proteins 9 and 10 (BMP9/BMP10). HHT2 patients frequently develop brain arteriovenous malformations (bAVMs), which are abnormal connections between arteries and veins. Currently, surgical resection is the only treatment, associat...

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Literature Corpus work: 5466bf22-1886-5ae0-887c-bb0a38ca81b8
DOI: 10.1101/2025.06.05.657957

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