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Article

Interaction between alk1 and blood flow in the development of arteriovenous malformations

9 Mar 2011

Abstract excerpt

Arteriovenous malformations (AVMs) are fragile direct connections between arteries and veins that arise during times of active angiogenesis. To understand the etiology of AVMs and the role of blood flow in their development, we analyzed AVM development in zebrafish embryos harboring a mutation in activin receptor-like kinase I (alk1), which encodes a TGFβ family type I receptor implicated in the human vascular...

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Share to Vascular Anomalies and Treatments
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PMID: 21389051
DOI: 10.1242/dev.060467

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