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Arterial endothelial deletion of hereditary hemorrhagic telangiectasia 2/ <i>Alk1</i> causes epistaxis and cerebral microhemorrhage with aberrant arteries and defective smooth muscle coverage

2024-11-28

Abstract excerpt

Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant vascular disorder with manifestations including severe nose bleeding and microhemorrhage in brains. Despite being the second most common inherited bleeding disorder, the pathophysiological mechanism underlying HHT-associated hemorrhage is poorly understood. HHT pathogenesis is thought to follow a Knudsonian two-hit model, requiring a second somat...

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Literature Corpus work
4e116942-983f-52d5-b793-d6de3e782cfa
DOI
10.1101/2024.11.25.622742
Open publication

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Arterial endothelial deletion of hereditary hemorrhagic telangiectasia 2/ <i>Alk1</i> causes epistaxis and cerebral microhemorrhage with aberrant arteries and defective smooth muscle coverageDOI 10.1101/2024.11.25.622742
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