Article

Targeting stiffness-dependent YAP/TAZ restores angiogenesis dynamics impaired by ALK1 knockout <i>in silico</i>

2025-09-29

Abstract excerpt

Hereditary Hemorrhagic Telangiectasia (HHT) is a currently uncurable genetic disorder caused by loss-of-function mutations in the ALK1-BMP9 pathway, leading to dysregulated angiogenesis and consequential vascular malformations. Recent experiments also implicate the mechanotransducers YAP/TAZ in HHT pathology. However, how YAP/TAZ stiffness sensitivity and signaling activity contribute to aberrant HHT angiogenesis...

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Literature Corpus work: e82b158d-7889-5260-950b-aac5b386e641
DOI: 10.1101/2025.09.26.678712

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