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Article

PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia

29 Nov 2016

Abstract excerpt

Activin receptor-like kinase 1 (ALK1) is an endothelial serine-threonine kinase receptor for bone morphogenetic proteins (BMPs) 9 and 10. Inactivating mutations in the ALK1 gene cause hereditary haemorrhagic telangiectasia type 2 (HHT2), a disabling disease characterized by excessive angiogenesis with arteriovenous malformations (AVMs). Here we show that inducible, endothelial-specific homozygous Alk1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27897192
DOI: 10.1038/ncomms13650

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