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Article

Enhanced responses to angiogenic cues underlie the pathogenesis of hereditary hemorrhagic telangiectasia 2.

PloS one - 1 Jan 2013

Choi Eun-Jung, Kim Yong Hwan, Choe Se-woon, Tak Yu Gyoung, Garrido-Martin Eva M, Chang Myron, Lee Young Jae, Oh S Paul

Abstract excerpt

Hereditary Hemorrhagic Telangiectasia (HHT) is a genetic vascular disease in which arteriovenous malformations (AVMs) manifest in skin and multiple visceral organs. HHT is caused by heterozygous mutations in endoglin (ENG), activin receptor-like kinase 1 (ALK1), or SMAD4. ALK1 regulates angiogenesis, but the precise function of ALK1 in endothelial cells (ECs) remains elusive. Since most blood vessels of HHT...

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Source

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Identifiers

PMID: 23675457
DOI: 10.1371/journal.pone.0063138
PMCID: PMC3651154

Genes

ENG
SMAD1
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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