Article

Blood flow regulates <i>acvrl1</i> transcription via ligand-dependent Alk1 activity

2024-01-25

Abstract excerpt

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disease characterized by the development of arteriovenous malformations (AVMs) that can result in significant morbidity and mortality. HHT is caused primarily by mutations in bone morphogenetic protein receptors ACVRL1 /ALK1, a signaling receptor, or endoglin ( ENG ), an accessory receptor. Because overexpression of Acvrl1 prevents AVM develop...

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Literature Corpus work: 1a7810e9-1b1b-5bc5-8901-a49dd5563912
DOI: 10.1101/2024.01.25.576046

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