Article

LRP1 and SORL1 regulate tau internalization and degradation and enhance tau seeding

2020-11-17

Abstract excerpt

<h4>ABSTRACT</h4> The identification of the apoE receptor, LRP1, as an endocytic receptor for tau raises several questions about LRP1s’ role in tauopathies. Is internalized tau, like other LRP1 ligands, delivered to lysosomes for degradation? Does LRP1 internalize pathological tau leading to cytosolic seeding? Do other, related receptors participate in these processes? We confirm that LRP1 rapidly internalizes ta...

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Literature Corpus work: f694bfe0-b27c-5559-98f5-03bf734b9346
DOI: 10.1101/2020.11.17.386581

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