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SORL1 is a receptor for tau that promotes tau seeding

22 Apr 2024

Abstract excerpt

Sortilin-related receptor 1 (SORL1) is an intracellular sorting receptor genetically implicated in Alzheimer's disease (AD) that impacts amyloid precursor protein trafficking. The objective of these studies was to test the hypothesis that SORL1 binds tau, modulates its cellular trafficking and impacts the aggregation of cytoplasmic tau induced by pathological forms of tau. Using surface plasmon resonance...

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PMID: 38657864
DOI: 10.1016/j.jbc.2024.107313

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