Article

LRP1 Triggers Pro-inflammatory Cell-signaling in Response to Extracellular Tau Independently of the NMDA Receptor

2023-10-07

Abstract excerpt

<h4>ABSTRACT</h4> In Alzheimer’s Disease (AD) and other neurodegenerative diseases, microtubule-associated protein Tau forms abnormal intracellular aggregates. The mechanisms by which Tau may promote AD progression remain incompletely understood. Injured and dying neurons release Tau into the extracellular spaces in the CNS. The released Tau may be taken up by receptors in the LDL Receptor gene family, including...

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Literature Corpus work: e8ed94ed-e696-51e2-b221-e64c60648329
DOI: 10.1101/2023.10.06.561299

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