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<i>In vivo</i> evidence that <i>SORL1</i> , encoding the endosomal recycling receptor SORLA, can function as a causal gene in Alzheimer’s Disease

2021-07-13

Abstract excerpt

<h4>ABSTRACT</h4> The few established causal genes in Alzheimer’s disease (AD), mutations in APP and PSENs, have been functionally characterized using biomarkers, capturing an in vivo profile reflecting the disease’s initial preclinical phase. SORL1 , a gene encoding the endosome recycling receptor SORLA, epidemiologically behaves as a causal gene when truncating mutations lead to partial loss of protein func...

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Literature Corpus work
c24b3ac9-034e-59f5-ad78-424f2d575d7f
DOI
10.1101/2021.07.13.452149
Open publication

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