Article

Ribotoxic collisions on CAG expansions disrupt proteostasis and stress responses in Huntington’s Disease

2022-05-05

Abstract excerpt

<h4>Summary</h4> Huntington’s disease (HD) is a devastating neurodegenerative disorder caused by CAG trinucleotide repeat expansions encoding a polyglutamine (polyQ) tract in the Huntingtin ( HTT ) gene 1 . Although mutant HTT (mHTT) protein tends to aggregate, the exact causes of neurotoxicity in HD remain unclear 2 . Here we show that altered elongation kinetics on CAG expansions cause ribosome collisions th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f678bea3-371e-56b9-a6e2-d05dab032f9c
DOI: 10.1101/2022.05.04.490528

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ribotoxic collisions on CAG expansions disrupt proteostasis and stress responses in Huntington’s DiseaseDOI 10.1101/2022.05.04.490528Read

Global ribosome profiling reveals that mutant huntingtin stalls ribosomes and represses protein synthesis independent of fragile X mental retardation proteinSemantic proximity Read

Tau-induced ribosomal collisions impair memory through the activation of the integrated stress responseSemantic proximity Read

RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress responseSemantic proximity Read

Formation and persistence of polyglutamine aggregates in mistranslating cells.Semantic proximity Read

Protein misfolding inside cells: The case of huntingtin and Huntington's diseaseSemantic proximity Read

Ribosome Profiling Reveals a Dichotomy Between Ribosome Occupancy of Nuclear-Encoded and Mitochondrial-Encoded OXPHOS mRNA Transcripts in a Striatal Cell Model of Huntington DiseaseSemantic proximity Read

A role of cellular translation regulation associated with toxic Huntingtin proteinSemantic proximity Read

Conformational diversity of collided ribosomes determines stress signalingSemantic proximity Read

A distal promoter and aberrant splicing enable canonical translation of out-of-frame proteins in Huntington’s diseaseSemantic proximity Read

New developments in Huntington’s disease and other triplet repeat diseases: DNA repair turns to the dark sideSemantic proximity Read

A stress-induced Tyrosine tRNA depletion response mediates codon-based translational repression and growth suppressionSemantic proximity Read

Targeted 3’-end RNA sequencing uncovers cryptic polyadenylation in Huntington’s disease linked to somatic instability and CAG repeat puritySemantic proximity Read