Article

A role of cellular translation regulation associated with toxic Huntingtin protein

2019-07-01

Abstract excerpt

Huntington’s disease (HD) is a severe neurodegenerative disorder caused by poly Q repeat expansion in the Huntingtin (Htt) gene. While the Htt amyloid aggregates are known to affect many cellular processes, its role in translation is not addressed. Here we report pathogenic Htt expression causes protein synthesis deficit in cells. We find a functional prion-like protein, the translation regulator Orb2 to be seques...

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Literature Corpus work: 5a1673bd-bf70-5a35-be40-128bb6587d6a
DOI: 10.1101/687764

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