Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response

4 Dec 2017

Abstract excerpt

Abstract Repeat-associated non-AUG (RAN) translation allows for unconventional initiation at disease-causing repeat expansions. As RAN translation contributes to pathogenesis in multiple neurodegenerative disorders, determining its mechanistic underpinnings may inform therapeutic development. Here we analyze RAN translation at G4C2 repeat expansions that cause C9orf72-associated amyotrophic lateral sclerosis and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to Endoplasmic Reticulum Stress and Disease
Share to Genetic Neurodegenerative Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29222490
DOI: 10.1038/s41467-017-02200-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress responsePMID 29222490Read ↗

C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylationSemantic proximity Read ↗

CGG Repeat-Associated Non-AUG Translation Utilizes a Cap-Dependent Scanning Mechanism of Initiation to Produce Toxic Proteins.Semantic proximity Read ↗

eIF5 stimulates the CUG initiation of RAN translation of poly-GA dipeptide repeat protein (DPR) in C9orf72 FTLD/ALSSemantic proximity Read ↗

Ribosome profiling reveals novel regulation of C9ORF72 GGGGCC repeat-containing RNA translationSemantic proximity Read ↗

CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcriptsSemantic proximity Read ↗

Ribosomal quality control factors inhibit repeat-associated non-AUG translation from GC-rich repeatsSemantic proximity Read ↗

RNA regulates repeat-associated non-AUG (RAN) translation initiation in <i>C9orf72</i> FTD/ALSSemantic proximity Read ↗

Repeat-associated non-ATG (RAN) translation in neurological disease.Semantic proximity Read ↗

Repeat-associated non-ATG (RAN) translation.Semantic proximity Read ↗

Comparative analysis of RAN translation from CAG repeats within the Huntingtin coding sequenceSemantic proximity Read ↗

Near-cognate initiation generates FMRpolyG from CGG repeats in Fragile X associated Tremor Ataxia SyndromeSemantic proximity Read ↗

Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent integrated stress response in C9orf72 FTD/ALSSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.