Article

Conformational diversity of collided ribosomes determines stress signaling

2026-06-17

Abstract excerpt

<h4>Abstract/summary</h4> Translating ribosomes are stalled by amino acid starvation and by chemical damage of the mRNA template, leading to ribosome collisions. These collisions serve as signaling platforms that promote quality control (QC) pathways that clear stalled ribosomes, and when sufficiently abundant, induce general stress responses, including the integrated stress response (ISR) mediated by the kinase...

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Literature Corpus work: e838425c-64bc-5133-8b20-d13068631a8e
DOI: 10.64898/2026.06.16.730951

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