Article

A distal promoter and aberrant splicing enable canonical translation of out-of-frame proteins in Huntington’s disease

2025-10-20

Abstract excerpt

Expanded CAG trinucleotide repeats cause more than a dozen neurodegenerative diseases, including Huntington’s disease (HD). In several disorders, these repeats are translated in multiple reading frames without identifiable AUG start codons. This process, called repeat-associated non-AUG (RAN) translation, generates aggregation-prone proteins, but its molecular basis remains unclear. Here, using affinity capture of...

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Literature Corpus work: b6e87f87-d87c-5e6b-b7b6-b1441ec9a949
DOI: 10.1101/2025.10.20.683480

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