Article

Targeted 3’-end RNA sequencing uncovers cryptic polyadenylation in Huntington’s disease linked to somatic instability and CAG repeat purity

2026-01-03

Abstract excerpt

<h4>ABSTRACT</h4> Huntington’s disease (HD) is a progressive neurodegenerative disorder caused by expanded CAG repeats in the first exon of the HTT gene, which encodes for huntingtin (HTT) protein. Full-penetrance is established at 40 repeats, but beyond, somatic repeat instability in the brain and CAG repeat purity modulate disease onset and severity. Previous studies have described that expanded repeats induce...

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Literature Corpus work: bfe3a664-1f7c-5e3e-acb0-75f90f91853d
DOI: 10.64898/2026.01.03.697463

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