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Protein misfolding inside cells: The case of huntingtin and Huntington's disease

28 Aug 2008

Abstract excerpt

Huntington's disease is one of the several neurodegenerative diseases caused by dominant mutations that expand the number of glutamine codons within an existing poly-glutamine (polyQ) repeat sequence of a gene. An expanded polyQ sequence in the huntingtin gene is known to cause the huntingtin protein to aggregate and form intracellular inclusions as disease progresses. However, the role that polyQ-induced...

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PMID: 18756529
DOI: 10.1002/iub.111

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