Article
Formation and persistence of polyglutamine aggregates in mistranslating cells.
Nucleic acids research - 18 Nov 2021
Lant Jeremy T, Kiri Rashmi, Duennwald Martin L, O'Donoghue Patrick
Abstract excerpt
In neurodegenerative diseases, including pathologies with well-known causative alleles, genetic factors that modify severity or age of onset are not entirely understood. We recently documented the unexpected prevalence of transfer RNA (tRNA) mutants in the human population, including variants that cause amino acid mis-incorporation. We hypothesized that a mistranslating tRNA will exacerbate toxicity and modify...
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