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New developments in Huntington’s disease and other triplet repeat diseases: DNA repair turns to the dark side

2 Nov 2020

Abstract excerpt

Abstract Huntington’s disease (HD) is a fatal, inherited neurodegenerative disease that causes neuronal death, particularly in medium spiny neurons. HD leads to serious and progressive motor, cognitive and psychiatric symptoms. Its genetic basis is an expansion of the CAG triplet repeat in the HTT gene, leading to extra glutamines in the huntingtin protein. HD is one of nine genetic diseases in this polyglutamine...

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PMID: 33224521
DOI: 10.1042/ns20200010

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