Article

Tau-induced ribosomal collisions impair memory through the activation of the integrated stress response

2026-01-13

Abstract excerpt

The formation of new long-term memories is reliant upon the spatial and temporal regulation of mRNA translation. Translational control has been demonstrated to be disrupted in neurodegenerative diseases, which exhibit impairments in both homeostatic translation and memory formation, such as Alzheimer’s disease (AD) and frontotemporal dementia (FTD). However, the precise mechanisms by which this dysregulation occur...

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Literature Corpus work: 6b9dd0c4-20b9-546d-a4d9-37be69a60bb9
DOI: 10.64898/2026.01.12.699151

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