Article

Structures reveal opening of the store-operated calcium channel Orai

2018-03-17

Abstract excerpt

The store-operated calcium (Ca 2+ ) channel Orai governs Ca 2+ influx through the plasma membrane of many non-excitable cells in metazoans. The channel opens in response to depletion of Ca 2+ within the endoplasmic reticulum (ER). Loss- and gain-of-function mutants of Orai cause disease. Our previous work revealed the structure of Orai with a closed pore. Here, using a gain-of-function mutation that constitutiv...

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Literature Corpus work: f670c49e-8c2c-517f-a152-9c6fadac75d3
DOI: 10.1101/284034

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