Article

Ca <sup>2+</sup> -inactivation of the mammalian ryanodine receptor type 1 in a lipidic environment revealed by cryo-EM

2021-11-15

Abstract excerpt

Activation of the intracellular Ca 2+ channel ryanodine receptor (RyR) triggers a cytosolic Ca 2+ surge, while elevated cytosolic Ca 2+ inhibits the channel in a negative feedback mechanism. Cryo-EM carried out under partially inactivating Ca 2+ conditions revealed two conformations of RyR1, an open state and an inactivated state, resolved at 4.0 and 3.3 Å resolution, respectively. RyR1s were embedded in nanod...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f7c0a2b5-1a95-575d-b14f-df707a0c4829
DOI: 10.1101/2021.11.14.468550

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ca <sup>2+</sup> -inactivation of the mammalian ryanodine receptor type 1 in a lipidic environment revealed by cryo-EMDOI 10.1101/2021.11.14.468550Read

Investigating dual Ca <sup>2+</sup> modulation of the ryanodine receptor 1 by molecular dynamics simulationSemantic proximity Read

Ryanodine Receptor Structure and Function in Health and Disease.Semantic proximity Read

Structural Details of the Ryanodine Receptor Calcium Release Channel and Its Gating Mechanism.Semantic proximity Read

Catching the next wave of recombinant RyR2 cryo-EM structures. Commentary on "Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations".Semantic proximity Read

Ryanodine receptors: structure and function.Semantic proximity Read

Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2.Semantic proximity Read

Molecular mechanism of the severe MH/CCD mutation Y522S in skeletal ryanodine receptor (RyR1) by cryo-EM.Semantic proximity Read

Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders.Semantic proximity Read

Toward decrypting the allosteric mechanism of the ryanodine receptor based on coarse-grained structural and dynamic modeling.Semantic proximity Read

Intracellular Ca2+ Sensing: Its Role in Calcium Homeostasis and Signaling.Semantic proximity Read

Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations.Semantic proximity Read

Investigating dual Ca2+ modulation of the ryanodine receptor 1 by molecular dynamics simulation.Semantic proximity Read