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Article

Structures reveal opening of the store-operated calcium channel Orai.

eLife - 30 Aug 2018

Hou Xiaowei, Burstein Shana R, Long Stephen Barstow

Abstract excerpt

The store-operated calcium (Ca2+) channel Orai governs Ca2+ influx through the plasma membrane of many non-excitable cells in metazoans. The channel opens in response to the depletion of Ca2+ stored in the endoplasmic reticulum (ER). Loss- and gain-of-function mutants of Orai cause disease. Our previous work revealed the structure of Orai with a closed pore. Here, using a gain-of-function mutation that...

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Identifiers

PMID: 30160233
DOI: 10.7554/eLife.36758
PMCID: PMC6170153

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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