Article

Molecular mechanisms of gating in the calcium-activated chloride channel bestrophin

2018-10-01

Abstract excerpt

Bestrophin (BEST1–4 in humans) channels are ligand gated chloride (Cl − ) channels that are activated by calcium (Ca 2+ ). Mutations in BEST1 cause retinal degenerative diseases. Partly because these channels have no sequence or structural similarity to other ion channels, the molecular mechanisms underlying gating are unknown. Here, we present a series of cryo-electron microscopy (cryo-EM) structures of chicken...

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Literature Corpus work: 7096bbfc-3455-5be5-bec9-d261b16cf29d
DOI: 10.1101/432682

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