Article

Catalytically Enhanced Cas9 through Directed Protein Evolution

2020-07-01

Abstract excerpt

The Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-Cas9 system has found widespread applications in genome manipulations due to its simplicity and effectiveness. Significant efforts in enzyme engineering have been made to improve the CRISPR-Cas9 systems beyond their natural power with additional functionalities such as DNA modification, transcriptional regulation, and high target selectivity 1–...

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Literature Corpus work: f62a39f5-12c3-516e-96d7-80b39919b1da
DOI: 10.1101/2020.07.01.183194

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