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Lasso peptides sviceucin and siamycin I have anti-virulence activity and restore vancomycin effectiveness in vancomycin-resistant <i>Enterococcus</i> sp. and <i>Staphylococcus aureus</i>

2024-07-30

Abstract excerpt

Antibiotic resistance is a major threat to human health and new drugs are urgently needed. Ideally, these drugs should have several cellular targets in pathogens, decreasing the risk of resistance development. We show here that two natural ribosomally-synthesized lasso peptides (LP), sviceucin and siamycin I, (i) abolish bacterial virulence of pathogenic enterococci, (ii) restore vancomycin clinical susceptibility...

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Literature Corpus work
f61af8df-6793-56b8-9b3d-31fcef4ba7ad
DOI
10.1101/2024.07.30.605797
Open publication

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Lasso peptides sviceucin and siamycin I have anti-virulence activity and restore vancomycin effectiveness in vancomycin-resistant <i>Enterococcus</i> sp. and <i>Staphylococcus aureus</i>DOI 10.1101/2024.07.30.605797
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