Article
From Vancomycin to Oritavancin: The Discovery and Development of a Novel Lipoglycopeptide Antibiotic
2010-01-01
Abstract excerpt
The introduction of penicillin in the 1940s, erythromycin in the 1950s and methicillin in the 1960s was quickly followed in each case by appearance of resistance to these antibiotics. By comparison, glycopeptide resistance required nearly thirty years to appear following clinical introduction of vancomycin. The reason for the delay is likely related to the clever mechanism of action of glycopeptide antibiotics. Th...
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Identifiers and source
- Literature Corpus work
- e69e7830-d708-50ec-b6d4-1b7dbc053e00
- DOI
- 10.2174/187152110790886745