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Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant <i>Enterococcus faecium</i>

2025-09-11

Abstract excerpt

Vancomycin-resistant Enterococcus faecium (VREfm) is a leading cause of healthcare-associated infections globally and demands new approaches for treatment. Here we show that genetic and pharmacological inactivation of a highly conserved NlpC/P60 peptidoglycan hydrolase, secreted antigen A (SagA), enhanced vancomycin susceptibility of VREfm ex vivo and in vivo . Notably, genetic deletion of sagA impaired VREfm...

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Literature Corpus work
1a13cb88-2729-5afc-b64c-d6f27bbbdee9
DOI
10.1101/2025.09.11.675460
Open publication

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Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant <i>Enterococcus faecium</i>DOI 10.1101/2025.09.11.675460
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