Article

A Broad Spectrum Lasso Peptide Antibiotic Targeting the Bacterial Ribosome

2024-09-16

Abstract excerpt

<title>Abstract</title> <p>Lasso peptides, biologically active molecules with a distinct structurally constrained knotted fold, are natural products belonging to the class of ribosomally-synthesized and posttranslationally modified peptides (RiPPs). Lasso peptides act upon several bacterial targets, but none have been reported to inhibit the ribosome, one of the main antibiotic targets in the bacterial cell. Here...

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Literature Corpus work: 04ce4211-2778-54e2-abc3-2aed173b5bcb
DOI: 10.21203/rs.3.rs-5058118/v1

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