β-Lactones as Specific Inhibitors of ClpP Attenuate the Production of Extracellular Virulence Factors of <i>Staphylococcus aureus</i>

Abstract excerpt

To approach the daunting problem of multidrug resistant bacterial pathogens, a multidisciplinary chemical proteomic strategy was applied and functionalized beta-lactones were identified as potent, cell permeable inhibitors for specific and selective targeting of the key virulence regulator complex ClpP in S. aureus and methicillin resistant S. aureus (MRSA) strains. ClpP represents the central protease complex...

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