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Cervimycin-Resistant Staphylococcus aureus Strains Display Vancomycin-Intermediate Resistant Phenotypes.

Microbiology spectrum - 26 Oct 2022

Dietrich Alina, Steffens Ursula, Gajdiss Mike, Boschert Anna-Lena, Dröge Jana Katharina, Szekat Christiane, Sass Peter, Malik Imran T, Bornikoel Jan, Reinke Laura, Maček Boris, Franz-Wachtel Mirita, Nieselt Kay, Harbig Theresa, Scherlach Kirstin, Brötz-Oesterhelt Heike, Hertweck Christian, Sahl Hans-Georg, Bierbaum Gabriele

Abstract excerpt

Resistance to antibiotics is an increasing problem and necessitates novel antibacterial therapies. The polyketide antibiotics cervimycin A to D are natural products of Streptomyces tendae HKI 0179 with promising activity against multidrug-resistant staphylococci and vancomycin-resistant enterococci. To initiate mode of action studies, we selected cervimycin C- and D-resistant (CmR) Staphylococcus aureus strains....

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Identifiers

PMID: 36173303
DOI: 10.1128/spectrum.02567-22
PMCID: PMC9603734

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