Article
Sortase A Inhibition: Updated Review of Non-Peptide Ligands for Targeting Staphylococcus Aureus Virulence
2025-07-29
Abstract excerpt
Sortases are a class of bacterial enzymes that are responsible for altering surface proteins and supporting attachment to host cells and enhancing biofilm formation, which poses resistance to the anti-virulence therapy. These enzymes are found in Gram-positive bacteria and can be classified into classes A-F. Sortase A, found in Staphylococcus aureus, is the prototype member of the sortase family and acts as the p...
Topics
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- Antimicrobial Peptides and Activities
- Antimicrobial Resistance in Staphylococcus
- Bacterial biofilms and quorum sensing
- Bacteriophages and microbial interactions
- Biochemical and Structural Characterization
- Microbial infections and disease research
- Monoclonal and Polyclonal Antibodies Research
- Streptococcal Infections and Treatments
Identifiers and source
- Literature Corpus work
- 010c68d9-4f27-50b3-b126-1da3d92898df
- DOI
- 10.22541/au.175376729.98473264/v1