Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lasso peptides sviceucin and siamycin I exhibit anti-virulence activity and restore vancomycin effectiveness in vancomycin-resistant pathogens

30 Jan 2025

Abstract excerpt

Antibiotic resistance is a major threat to human health and new drugs are urgently needed. Ideally, these drugs should have several cellular targets in pathogens, decreasing the risk of resistance development. We show here that two natural ribosomally synthesized lasso peptides (LPs), sviceucin and siamycin I, (1) abolish bacterial virulence of pathogenic enterococci, (2) restore vancomycin clinical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimicrobial Peptides and Activities
Share to Antimicrobial Resistance in Staphylococcus
Share to Bacterial Identification and Susceptibility Testing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40034853
DOI: 10.1016/j.isci.2025.111922

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lasso peptides sviceucin and siamycin I exhibit anti-virulence activity and restore vancomycin effectiveness in vancomycin-resistant pathogensPMID 40034853Read ↗

Lasso peptides sviceucin and siamycin I have anti-virulence activity and restore vancomycin effectiveness in vancomycin-resistant <i>Enterococcus</i> sp. and <i>Staphylococcus aureus</i>Semantic proximity Read ↗

Baohuoside I targets SaeR as an antivirulence strategy to disrupt MRSA biofilm formation and pathogenicitySemantic proximity Read ↗

Cervimycin-Resistant Staphylococcus aureus Strains Display Vancomycin-Intermediate Resistant Phenotypes.Semantic proximity Read ↗

Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant <i>Enterococcus faecium</i>Semantic proximity Read ↗

Thwarting resistance: MgrA inhibition with methylophiopogonanone a unveils a new battlefront against S. aureusSemantic proximity Read ↗

Sortase A Inhibition: Updated Review of Non-Peptide Ligands for Targeting Staphylococcus Aureus VirulenceSemantic proximity Read ↗

Old and New Glycopeptide Antibiotics: Action and ResistanceSemantic proximity Read ↗

Beyond killingSemantic proximity Read ↗

Targeting Virulence in Staphylococcus aureus by Chemical Inhibition of the Accessory Gene Regulator System In VivoSemantic proximity Read ↗

From Vancomycin to Oritavancin: The Discovery and Development of a Novel Lipoglycopeptide AntibioticSemantic proximity Read ↗

Molecular Events for Promotion of Vancomycin Resistance in Vancomycin Intermediate Staphylococcus aureusSemantic proximity Read ↗

A mechanistic understanding of the effect of Staphylococcus aureus VraS histidine kinase single-point mutation on antibiotic resistanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.