Back to search

Article

A mechanistic understanding of the effect of <i>Staphylococcus aureus</i> VraS histidine kinase single point mutation on antibiotic resistance

2025-01-06

Abstract excerpt

Bacterial genomic mutations in Staphylococcus aureus (S. aureus) have been detected in isolated resistant clinical strains, yet their mechanistic effect on the development of antimicrobial resistance remains unclear. The resistance-associated regulatory systems acquire adaptive mutations under stress conditions that may lead to a gain of function effect and contribute to the resistance phenotype. Here, we investi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ca560fde-91c7-5657-a59f-6eae46f90736
DOI
10.1101/2025.01.06.631495
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A mechanistic understanding of the effect of <i>Staphylococcus aureus</i> VraS histidine kinase single point mutation on antibiotic resistanceDOI 10.1101/2025.01.06.631495
A mechanistic understanding of the effect of Staphylococcus aureus VraS histidine kinase single-point mutation on antibiotic resistanceSemantic proximity
Staphylococcus aureus sensor histidine kinase VraS mutations linked to antibiotic resistance affect enzymatic catalysis, stability, and substrate interactions.Semantic proximity
Strain-resolved CRISPRi-Seq reveals conserved antibiotic vulnerabilities in <i>Staphylococcus aureus</i>Semantic proximity
Site-specific mutation of Staphylococcus aureus VraS reveals a crucial role for the VraR-VraS sensor in the emergence of glycopeptide resistance.Semantic proximity
Evolution of multidrug resistance during Staphylococcus aureus infection involves mutation of the essential two component regulator WalKR.Semantic proximity
An induced mutation of ABC-transporter component VraF(K84E) contributes to vancomycin resistance and virulence in Staphylococcus aureus strain MW2.Semantic proximity
The VanS sensor histidine kinase from type-B VRE recognizes vancomycin directlySemantic proximity
Molecular Events for Promotion of Vancomycin Resistance in Vancomycin Intermediate Staphylococcus aureusSemantic proximity
Staphylococcus aureus response and adaptation to vancomycin.Semantic proximity
A Close-up View of the VraSR Two-component SystemSemantic proximity
Mechanisms of vancomycin resistance in Staphylococcus aureus.Semantic proximity
Insights into the molecular basis of reduced vancomycin susceptibility among three prominent Staphylococcus aureus clonal complexesSemantic proximity
Select a neighboring publication to make it the new centre.