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Profiling the <i>in vitro</i> and <i>in vivo</i> activity of streptothricin-F against carbapenem-resistant Enterobacterales: a historic scaffold with a novel mechanism of action

2021-06-15

Abstract excerpt

<h4>ABSTRACT</h4> Streptothricins are components of the natural product, nourseothricin; each containing identical streptolidine and gulosamine aminosugar moieties attached to varying numbers of linked β-lysines. Nourseothricin was discovered by Waksman and colleagues in the early 1940’s, generating intense interest because of excellent Gram-negative activity. However, the natural product mixture was associated w...

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Literature Corpus work
0a1544f0-16ad-5c21-8707-0f4f5691a2e3
DOI
10.1101/2021.06.14.448463
Open publication

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Profiling the <i>in vitro</i> and <i>in vivo</i> activity of streptothricin-F against carbapenem-resistant Enterobacterales: a historic scaffold with a novel mechanism of actionDOI 10.1101/2021.06.14.448463
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