Article

Hepatic HIF2α modulates extra-hepatic disease-associated phenotypes during metabolic dysfunction-associated steatotic liver disease

2026-04-06

Abstract excerpt

Metabolic dysfunction-associated steatotic liver disease (MASLD) afflicts more than one-third of adults globally, contributing significantly to an increased cardiovascular disease risk. Further, patients with severe liver disease experience muscle weakness (sarcopenic obesity) and fatigue. Hypoxia-inducible factor 2α (HIF2α) accumulates in the livers of MASLD patients and has been implicated in disease progression...

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Literature Corpus work: f5fbd9ea-7537-50f5-9d5b-179289806068
DOI: 10.64898/2026.04.02.716074

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