Article

Obesity and diabetes related disturbances in systemic metabolism induce a cardiometabolic heart failure with preserved ejection fraction phenotype in a combined high-fat, high sucrose diet and streptozotocin mouse model

2025-10-24

Abstract excerpt

<h4>Background</h4> Diabetes and obesity are associated with an increased incidence of heart failure with preserved ejection fraction (HFpEF), but the underlying pathophysiological mechanisms are poorly understood. A shortage of appropriate preclinical mouse models reflecting different pathophysiological disease aspects might contribute to this inadequate understanding of the complex and diverse HFpEF pathophysio...

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Literature Corpus work: b1cba4d2-15ed-5117-94ca-8e0b8537ba0c
DOI: 10.1101/2025.10.23.684124

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