Article

Mechanistic Links Between Metabolic Dysfunction-Associated Steatotic Liver Disease and Heart Failure with Preserved Ejection Fraction in a Mouse Model

2025-11-03

Abstract excerpt

<h4>Background</h4> Metabolic dysfunction-associated steatotic liver disease (MASLD) commonly coexists with heart failure with preserved ejection fraction (HFpEF), yet the mechanisms linking hepatic steatosis to diastolic dysfunction remain unclear. <h4>Methods</h4> A combined murine model of pressure overload using transverse aortic constriction (TAC) and diet-induced MASLD was developed to investigate the live...

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Literature Corpus work: c1d33c84-8227-5a2a-84e5-7c7f75447529
DOI: 10.1101/2025.11.02.686066

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