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Exercise ameliorates sarcopenia and metabolic dysfunction–associated steatohepatitis through activation of skeletal muscle PGC-1α/SIRT1 signaling in mice

2026-08-20

Abstract excerpt

<title>Abstract</title> <p> Sarcopenia is a common complication of metabolic dysfunction–associated steatohepatitis (MASH); it leads to poor clinical outcomes. Although exercise is recommended for MASH and sarcopenia, the molecular mechanisms linking skeletal muscle adaptation to hepatic improvement remain unclear. We investigated the effects of exercise on muscle and liver pathology in an aged MASH mouse model....

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Literature Corpus work
eb9b7953-f28b-5438-b6fe-cf386c21534b
DOI
10.21203/rs.3.rs-10531752/v1
Open publication

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Exercise ameliorates sarcopenia and metabolic dysfunction–associated steatohepatitis through activation of skeletal muscle PGC-1α/SIRT1 signaling in miceDOI 10.21203/rs.3.rs-10531752/v1
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